MOTS-C 10mg

Description

MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16-amino acid peptide encoded within the mitochondrial genome — a distinction that separates it from nuclear-encoded peptides and has generated significant interest in mitochondrial biology and retrograde signaling research. First characterized by Lee et al. at the University of Southern California in 2015, MOTS-c was identified as a signal that travels from mitochondria to the nucleus in response to metabolic stress, a pathway researchers have framed as a form of mitochondrial hormesis.

The original characterization study demonstrated that MOTS-c activates AMPK and modulates the folate-methionine cycle, improving insulin sensitivity and reducing obesity-associated phenotypes in mice maintained on a high-fat diet (PubMed 25738455). Subsequent investigation identified MOTS-c as an exercise-responsive factor: plasma concentrations rise during physical exertion, and systemic administration in sedentary animal models produced metabolic adaptations resembling those observed with endurance training (PubMed search). Research groups continuing this work have reported that circulating MOTS-c concentrations decline with age and that restoration to youthful levels in aged models improved physical performance, reduced inflammatory markers, and extended healthspan parameters in multiple cohorts (PubMed search).

Active lines of investigation are examining MOTS-c’s role in stress response signaling, immune modulation, and skeletal metabolism. Each 10mg lyophilized vial is independently tested to >98% purity with a Certificate of Analysis on file.