NAD+ 1000mg

Description

NAD+ (nicotinamide adenine dinucleotide) is a dinucleotide coenzyme central to cellular redox reactions and energy metabolism, present in every living cell. Research interest has expanded considerably following discoveries linking declining NAD+ levels to aging, impaired mitochondrial function, reduced DNA repair capacity, and dysregulation of sirtuin proteins — a family of enzymes associated with longevity pathways.

A landmark investigation by Rajman et al. (2018) demonstrated that restoring NAD+ levels in aged animal models produced measurable improvements in vascular and muscle function comparable to younger cohorts, providing researchers with a framework for evaluating supplementation strategies across tissue types (PubMed 29514063). Imai and Guarente’s foundational review established the mechanistic link between NAD+, SIRT1/SIRT3 activation, and age-associated physiological decline, now considered a key reference for groups entering this field (PubMed search). Mills et al. separately published results from a long-term NMN administration study in which aged mice showed reversal of physiological decline across multiple organ systems, including improvements in energy metabolism, insulin sensitivity, and physical performance (PubMed 26971879).

Research teams extending this work have concentrated on NAD+’s role in PARP enzyme activity, mitochondrial biogenesis, and circadian clock regulation. Each 1000mg lyophilized vial is independently verified to >98% purity with a Certificate of Analysis on file.